产品说明
应用
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.
包装
50, 500 mg in poly bottle
生化/生理作用
Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.
Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.
其他说明
Keep container tightly closed in a dry and well-ventilated place.Light sensitive.
基本信息
| 经验(实验)分子式 | C21H21N · HCl |
| 分子量 | 323.86 |
| MDL编号 | MFCD00059047 |
| PubChem化学物质编号 | 329818590 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥99% |
| 形式 | powder |
| 溶解性 | ethanol: soluble 50 mg/mL |
| 抗生素抗菌谱 | Gram-negative bacteria Gram-positive bacteria fungi yeast |
| 作用机制 | cell wall synthesis | interferes enzyme | inhibits |
| 储存温度 | 2-8℃ |
| SMILES string | Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23 |
| InChI | 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+; |
| InChI key | OLUNPKFOFGZHRT-YGCVIUNWSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
