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NSC 663284

品牌
Sigma-Aldrich
CAS
383907-43-5
货号
N7537
规格纯度
≥98% (HPLC), solid
参考价格
2765.78 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

包装

5, 25 mg in glass bottle

生化/生理作用

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

基本信息

经验(实验)分子式C15H16ClN3O3
分子量321.76
MDL编号MFCD08276924
PubChem化学物质编号24724556
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
储存条件protect from light
颜色 red
溶解性DMSO: ≥10 mg/mL
H2O: insoluble
储存温度2-8℃
SMILES stringClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
InChI1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChI keyBMKPVDQDJQWBPD-UHFFFAOYSA-N
Gene Informationhuman ... CDC25B(994), DUSP3(1845), PTPN1(5770)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)470.1 °F
闪点(C)243.4 ℃
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

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