产品说明
应用
NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.
包装
5, 25 mg in glass bottle
生化/生理作用
NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
基本信息
经验(实验)分子式 | C15H16ClN3O3 |
分子量 | 321.76 |
MDL编号 | MFCD08276924 |
PubChem化学物质编号 | 24724556 |
NACRES | NA.77 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | solid |
储存条件 | protect from light |
颜色 | red |
溶解性 | DMSO: ≥10 mg/mL H2O: insoluble |
储存温度 | 2-8℃ |
SMILES string | ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O |
InChI | 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2 |
InChI key | BMKPVDQDJQWBPD-UHFFFAOYSA-N |
Gene Information | human ... CDC25B(994), DUSP3(1845), PTPN1(5770) |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | 470.1 °F |
闪点(C) | 243.4 ℃ |
个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |