Anti-Kallikrein 7 (KLK7) Antibody, clone 83-1

产品说明

一般描述

Kallikrein-7 (UniProt: P49862; also known as hK7, KLK7, Serine protease 6, Stratum corneum chymotryptic enzyme, hSCCE) is encoded by the KLK7 (also known as PRSS6, SCCE) gene (Gene ID: 5650) in human. KLK7 is a chymotrypsin-like serine protease of the member of peptidase S1 family. It is synthesized with a signal peptide of 22 amino acids (aa 1-22) and a propeptide region (aa 23-29) that are subsequently cleaved to generate the mature form. Human KLK7 displays about 40 to 60% amino acid homology with other members of the family. It cleaves proteins with aromatic side chains in the P1 position. KLK7 is abundantly expressed in the skin and is also present in the brain, mammary gland, cerebellum, spinal cord, and kidney. Lower levels of expression have been reported in in salivary glands, uterus, thymus, thyroid, placenta, trachea, and testis. Its levels are shown to be up-regulated in ovarian carcinoma, especially late-stage serous carcinoma. Less differentiated tumors of more advanced stage show higher level KLK7 expression. KLK7 activity is inhibited by zinc and copper ions.

特异性

Clone 83-1 detects Kallikrein -7 in human tissues.

免疫原

Full-length human recombinant Kallikrein-7.

应用

Anti-Kallikrein 7 (KLK7), clone 83-1, Cat. No. MABN2430, is a highly specific mouse monoclonal antibody that targets Kallikrein-7 and has been tested in ELISA and Western Blotting.
ELISA Analysis: A representative lot detected Kallikrein 7 (KLK7) in ELISA applications (Shan, S.J., et. al. (2006). Clin Chem. 52(10):1879-86; Kishi, T., et. al. (2004). Clin Chem. 50(4):709-16).

Research Category
Neuroscience

质量

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Kallikrein 7 (KLK7) in 10 µg of human brain tissue lysate.

目标描述

~27 kDa observed; 27.53 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外形

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.

Format: Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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