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Monoclonal Anti-NQO1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
WH0001728M1
规格纯度
clone 1E3-A6, purified immunoglobulin, buffered aqueous solution
参考价格
4435.79 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein′s enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer′s disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq)
NAD(P)H quinone dehydrogenase 1 (NQO1) is an obligate two-electron reductase. It is a cytoplasmic, homodimeric protein, with one FAD molecule per monomer. This gene is localized to human chromosome 16q23. It shows a wide range of tissue expression.

免疫原

NQO1 (AAH07659, 1 a.a. ~ 274 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK

生化/生理作用

NAD(P)H quinone dehydrogenase 1 (NQO1) uses NADH or NADPH as a reducing cofactor and is characterized by its inhibition by dicoumarol. It is thought to confer protection against natural and exogenous quinones. NQO1 is involved in the conversion of benzene derived quinones to less toxic hydroquinones and participates in benzene-associated hematotoxicity. It is involved in the reduction and eventual activation of few chemotherapeutic drugs and environmental carcinogens, such as heterocyclic amines, nitroaromatic compounds and possibly cigarette smoke particulate. NQO1 is up-regulated in serous ovarian carcinoma and this expression is linked with poor prognosis; hence, this gene has potential as a biomarker for the same.

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆1E3-A6, monoclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
同位素/亚型IgG1κ
GenBank® accession no.BC007659
UniProt登记号P15559
运输dry ice
储存温度−20℃
Gene Informationhuman ... NQO1(1728)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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