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Monoclonal Anti-C6orf32 antibody produced in mouse

品牌
Sigma-Aldrich
货号
WH0009750M1
规格纯度
clone 2E6-1B10, purified immunoglobulin, buffered aqueous solution
参考价格
4888.5 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

FAM65B (family with sequence similarity 65, member B), also known as chromosome 6 open reading frame 32 (C6ORF32), is mapped to human chromosome 6p22.3. FAM65B is known to be expressed during embryonic and postnatal development stages in cochlea. The encoded protein is found to concentrate in the plasma membranes of the stereocilia of inner and outer hair cells of the inner ear.

免疫原

C6orf32 (AAH01232.1, 1 a.a. ~ 591 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENSSALKKPQAKLKKMHNLGHKNNNPPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKLTAQLKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLTEINRSFKEYTENMCTIEVELENLLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGKIEVNGKQSWDGEETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDMTASSGAGNKAAALQRRMSMYSQGTPETPTFKDHSFFSNLPDDIFENGKAAEEKMPLSLSFSDLPNGDCALTSHSTGSPSNSTNPEITITPAEFNLSSLASQNEGMDDTSSASSRNSLGEGQEPKSHLKEEDPEEPRKPASAPSEACRRQSSGAGAEHLFLENDVAEALLQESEEASELKPVELDTSEGNITKQLVKRLTSAEVPMATDRLLSEGSVGGESEGCRSFLDGSLEDAFNGLLLALEPHKEQYKEFQDLNQEVMNLDDILKK

生化/生理作用

FAM65B (family with sequence similarity 65, member B) is recognized as a Ras homolog gene family, member A (RHOA) inhibitor and is involved in polarization. FAM65B regulates RhoA activity with the help of forkhead box O transcription factors. It binds to RhoA and blocks the GTP loading to RhoA. FAM65B deficiency in neutrophils leads to an increase in RhoA activity and causes defects in chemotaxis directionality and adhesion to endothelial cells under flow. It is involved in chemokine-stimulated migration and adhesion of Jurkat cells. Phosphorylation stabilizes FAM65B. FAM65B is a component of the inner ear and is involved in the process of hearing. Mutation in the gene is known to be associated with hearing loss in humans. FAM65B is associated with myotube formation and in the regulation of cell adhesion, polarization, and migration. Overexpression of the protein in myogenic and non-myogenic cells results in the formation of cellular protrusions. Hence, FAM65B might be involved in myoblast migration or cytoskeletal protein rearrangements that accompany myogenic differentiation.

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆2E6-1B10, monoclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型IgG2bκ
GenBank® accession no.BC001232
运输dry ice
储存温度−20℃
Gene Informationhuman ... FAM65B(9750)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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