产品说明
一般描述
MAGI-2 is composed of three domains including six PDZ, one guanylate kinase (GK) and two WW domain.
The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.2
MAGI-2 was initially identified in rat, as a protein interacting with N-methyl-D-aspartate receptors (NMDA-R) and neuronal cell adhesion proteins, and was named S-SCAM.4Three isoforms of S-SCAM were identified, of 1277, 1113 and 1053 amino acids length, respectively.5
免疫原
synthetic peptide corresponding to amino acids 554-571 of MAGI-2/S-SCAM conjugated to KLH.
应用
Anti-MAGI-2 antibody produced in rabbit has been used in immunoblotting and immunolabeling.
生化/生理作用
Membrane associated guanylate kinase inverted-2 (MAGI-2) as well as MAGI-3, was shown to interact with the tumor suppressor PTEN through one of its PDZ domains, apparently acting as a scaffolding protein that could assemble a multi subunit signaling complex. It is known to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.
外形
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
MDL编号 | MFCD03791836 |
NACRES | NA.46 |
产品性质
生物来源 | rabbit |
质量水平 | 200 |
偶联物 | unconjugated |
抗体形式 | IgG fraction of antiserum |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
species reactivity | rat |
technique(s) | microarray: suitable western blot: 1:250 using rat brain extracts |
UniProt登记号 | O88382 |
运输 | dry ice |
储存温度 | −20℃ |
Gene Information | rat ... Magi2(113970) |