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PI 3-Kinase (p110α(H1047R)/p85α), 10 μg

PI 3-Kinase (p110α(H1047R)/p85α), 10 μg

品牌
Sigma-Aldrich
货号
14-792-M
规格纯度
Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R & untagged, recombinant, human p85α full length.
参考价格
7209.41 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The H1047R substitution is a somatic mutation in p110α that has been associated with tumours of the colon, stomach, breast and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Samuels Y. et al., Science, (2004); 304: 554; Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).
Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R, and untagged, recombinant, human p85α full length.

生化/生理作用

Protein Target: PI3Kα/p85α
Target Sub-Family: PI3K/PI4K

包装

Also available in 250μg size --call for pricing and availability and reference catalog number 14-792M when ordering the 250μg size.

外形

50 mM Tris/HCl pH8.0, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
Ni2+/NTA-agarose

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160405
NACRESNA.32

产品性质

质量水平100
生物来源human
分子量Mw 125 kDa (p110α(H1047R))
Mw 84 kDa (p85α)
manufacturer/tradenameUpstate®
UniProt登记号P26450 (mouse)
P27986
P42336
P42337 (mouse)
U79143
Gene Informationhuman ... PIK3CA(5290)

安全信息

象形图GHS07
警示用语:Warning
危险声明H317
预防措施声明P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
危险分类Skin Sens. 1
储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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