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MAPKAP Kinase 2 Protein, active, 10 μg

品牌
Sigma-Aldrich
货号
14-337-M
规格纯度
Active, for use in Kinase Assays.
参考价格
7209.41 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Product Source: Human MAPKAP Kinase 2 expressed in E. coli.
Recombinant human MAPKAP Kinase 2, residues 46-400, A399G, containing an N-terminal GST tag.

MAPKAP Kinase 2 has been implicted as a cell cycle checkpoint kinase, joining the ranks of Chk1 and Chk2 as critical regulators of the DNA damage response in mammalian cells in recent studies (Manke, et al, 2005, and Abraham, 2005). This research indicates that MAPKAP Kinase 2, a serine/threonine kinase activated by p38, phosphorylates CDC25 B/C, generating a binding site for 14-3-3 proteins. The checkpoint kinases Chk1 and Chk2 are targets for drug discovery efforts designed to overcome cell cycle arrest due to DNA damage induced by chemotherapeutic agents. Overriding the checkpoint kinases in cancer cells exposed to DNA damaging agents leads to catastrophic failure of cell division and apoptosis.
The new role of MAPKAP Kinase 2 in complementing the function of Chk1 and Chk2 suggests a new target for drug discovery efforts.

生化/生理作用

Protein Target: MAPKAP-K2
Target Sub-Family: CAMK

包装

Also available in 250μg size as catalog # 14-337M - Call for pricing and availability.

质量

Routinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide

外形

GSH-agarose & Q-Sepharose FF

储存及稳定性

1 year at -20°C

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160405
NACRESNA.41

产品性质

质量水平100
生物来源human
分子量Mw 70.2 kDa
manufacturer/tradenameUpstate®
technique(s)activity assay: suitable (kinase)
NCBI登记号NM_004759.3
NM_032960.2
UniProt登记号P49137
Gene Informationhuman ... MAPKAPK2(9261)

安全信息

象形图GHS07
警示用语:Warning
危险声明H317
预防措施声明P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
危险分类Skin Sens. 1
储存分类代码12 - Non Combustible Liquids
WGKWGK 1

Sigma-Aldrich

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