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Smurf1, active

品牌
Sigma-Aldrich
货号
23-058-M
包装型号
规格纯度
参考价格
8720.59 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Smurf1 is a member of the Nedd4-like family of E3 ligases. It contains an amino terminal C2 domain and 2 WW domains that are responsible for cellular localization and substrate recognition, and a catalytic carboxyl terminal HECT domain.
Smurf1 was originally identified as a negative regulator of the TGF-β/BMP (bone morphogenetic proteins) signalling pathway by degrading SMAD proteins and TGF-β /BMP receptors. To date, over a dozen substrates have been identified, including Runx2, MEKK2, RhoA, Par6, JunB, Talin head, Prickle1, TRAF family proteins, and STAT1. This suggests a pleiotropic role for Smurf1 in various cellular functions such as bone homeostasis, embryonic development, cell movement and polarity control, and immune response. Aberrant expression of Smurfs has been shown to occur in several types of cancers, including breast, oesophageal, pancreatic and renal cell carcinomas.

应用

Ubiquitination Cascade Comoponent: E3

外形

Purified using glutathione sepharose.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160405
NACRESNA.41

产品性质

质量水平100
生物来源human
manufacturer/tradenameUpstate®
technique(s)activity assay: suitable
NCBI登记号NM_181349

安全信息

象形图GHS07
警示用语:Warning
危险声明H317
预防措施声明P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
危险分类Skin Sens. 1
储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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