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SCF-Fbw7 Protein Complex, Active, 10 μg

品牌
Sigma-Aldrich
货号
23-030-M
规格纯度
Active complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
参考价格
8537.29 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The SCF (Skp1-Cul1-F-box protein) complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFFbw7 mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell division, growth and differentiation, including Cyclin E1, c-Myc, Notch and c-Jun. Mutations have been found in the Fbw7 subunit of SCFFbw7 in various types of human cancers, therefore Fbw7 is considered to be a potent tumour suppressor.
N-terminal c-Myc, 6His-tagged, recombinant human Smad7 full length, expressed by baculovirus in Sf21 insect cells.

应用

Ubiquitination Cascade Comoponent: E3

外形

Purified using glutathione sepharose.

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160405
NACRESNA.41

产品性质

质量水平100
生物来源human
manufacturer/tradenameUpstate®
technique(s)activity assay: suitable
NCBI登记号NM_003592
NM_014248
NM_033632
NM_170679
Gene Informationhuman ... Cul1(8454), Fbw7(55294), Rbx1(9978), Skp1(6500)

Sigma-Aldrich

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