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Anti-LSD1 (AOF2) (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
L4418
规格纯度
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
7010.69 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Lysine specific demethylase 1 (LSD1) also known as amine oxidase flavin containing domain 2 (AOF2) is a lysine specific demethylase. It is a nuclear protein containing a Swi3p, Rsc8p and Moira (SWIRM) domain, a flavin adenine dinucleotide (FAD)-binding motif and an amine oxidase domain.

免疫原

synthetic peptide corresponding to amino acids 835-852 of human LSD1 (AOF2) (isoform b), conjugated to KLH via an N-terminal added cysteine reisidue. The immunizing sequence is present also in isoform a. This sequence is conserved in human, rat, and mouse.

应用

Anti-LSD1 (AOF2) (C-terminal) antibody produced in rabbit immunoblotting, immunoprecipitation and immunofluorescence.

生化/生理作用

Lysine specific demethylase 1 (LSD1) is a component of several histone deacetylase complexes that function through modifying chromatin structure to repress transcription. LSD1 (AOF2) action can signal either activation or repression of transcription. Demethylation of histone H3 Lys4 by LSD1 (AOF2) leads to transcriptional repression of target genes, while demethylation of histone H3 at Lys9 leads to de-repression of androgen receptor target genes. The activity of LSD1 (AOF2) is regulated by its associated factors. REST corepressor 1 (CoREST), a transcriptional corepressor, promotes demethylation by enhancing the association of LSD1 (AOF2) with the nucleosomes, and it also protects LSD1 (AOF2) from proteasomal degradation.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD09039194

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 110-115 kDa
species reactivitymouse (predicted), rat (predicted), human
浓度~1 mg/mL
technique(s)immunocytochemistry: 5-10 μg/mL using MCF7 cells fixed with formaldehyde
immunoprecipitation (IP): 1-2 μg using MCF7 cell lysates
western blot: 1-2 μg/mL using MCF7 cell lysates (2 bands, 2 isoforms)
运输dry ice
储存温度−20℃
Gene Informationhuman ... AOF2(23028)
mouse ... Aof2(99982)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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