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Luotonin A

骆驼宁碱A

品牌
Sigma-Aldrich
CAS
205989-12-4
货号
L4045
规格纯度
≥98% (HPLC)
参考价格
1675.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

10 mg in glass bottle
50 mg in poly bottle

生化/生理作用

Luotonin A is a cytotoxic alkaloid reported to inhibit topoisomerase I. Luotonin A was originally isolated from the Chinese medicinal plant Paganum nigellastrum. As an antitumor agent, Luotonin A demonstrates cytotoxic activity against the mouse leukemic cell line P-388 at low concentrations (IC50 1.8μg/mL). Luotonin A stabilizes the cleavable human topoisomerase I-DNA binary complex resulting in cytotoxicity to cells (IC50 5.07-12.6 μM).Luotonin forms non-covalent complexes with ds-DNA in the minor groove. It may serve as a prototype for analytical probes of DNA hybridization.

重悬

Solubility is tested at 4 mg/mL in 1:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.

基本信息

线性分子式C18H11N3O
NACRESNA.77

产品性质

质量水平200
生物来源synthetic (organic)
测定≥98% (HPLC)
形式solid
溶解性chloroform: methanol (1:1): 4 mg/mL, clear to slightly hazy, colorless to yellow
运输wet ice
储存温度−20℃
Gene Informationhuman ... TOP1(7150)

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P301 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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