产品说明
包装
10 mg in glass bottle
50 mg in poly bottle
生化/生理作用
Luotonin A is a cytotoxic alkaloid reported to inhibit topoisomerase I. Luotonin A was originally isolated from the Chinese medicinal plant Paganum nigellastrum. As an antitumor agent, Luotonin A demonstrates cytotoxic activity against the mouse leukemic cell line P-388 at low concentrations (IC50 1.8μg/mL). Luotonin A stabilizes the cleavable human topoisomerase I-DNA binary complex resulting in cytotoxicity to cells (IC50 5.07-12.6 μM).Luotonin forms non-covalent complexes with ds-DNA in the minor groove. It may serve as a prototype for analytical probes of DNA hybridization.
重悬
Solubility is tested at 4 mg/mL in 1:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.
基本信息
线性分子式 | C18H11N3O |
NACRES | NA.77 |
产品性质
质量水平 | 200 |
生物来源 | synthetic (organic) |
测定 | ≥98% (HPLC) |
形式 | solid |
溶解性 | chloroform: methanol (1:1): 4 mg/mL, clear to slightly hazy, colorless to yellow |
运输 | wet ice |
储存温度 | −20℃ |
Gene Information | human ... TOP1(7150) |
安全信息
象形图 | |
警示用语: | Danger |
危险声明 | H301 |
预防措施声明 | P301 + P310 |
危险分类 | Acute Tox. 3 Oral |
储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |