产品说明
生化/生理作用
PAK3 (p21 protein (Cdc42/Rac)-activated kinase 3) is a member of the family of serine/threonine protein kinases that serve as targets for the small GTPases, Cdc42 (cell division cycle 42) and RAC (AKT1, v-akt murine thymoma viral oncogene homolog 1). The PAK family of proteins has been implicated in a wide range of biological activities and are involved in the control of gene transcription, cell morphology, motility and cell death. A point mutation in PAK3 gene has been linked to nonsyndromic X-linked mental retardation. PAK3 is strongly expressed in brain, mainly in the hippocampus.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in baculovirus infected Sf9 cells |
| 产品线 | PRECISIO® Kinase |
| 测定 | ≥70% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| specific activity | 221-298 nmol/min·mg |
| 分子量 | ~89 kDa |
| UniProt登记号 | Q61036 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | mouse ... Pak3(18481) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
