产品说明
一般描述
The gene Jsrp1 (junctional sarcoplasmic reticulum protein 1), also referred to as JP45, encodes an integral protein that contains a predicted cytoplasmic domain, an intralumenal domain that is rich in positively charged amino acids, preceded by a single transmembrane segment. The mRNA has been detected in 17-day-old mouse embryos, with increased expression during the second month of postnatal development. Its expression decreases 3-fold during aging. The protein is localized to the junctional sarcoplasmic reticulum.
免疫原
rabbit skeletal muscle triads.
生化/生理作用
The gene Jsrp1 (junctional sarcoplasmic reticulum protein 1) encodes an integral protein component of the junctional face membrane of the skeletal muscle sarcoplasmic reticulum. It is found to associate with Cav1.1 (voltage-dependent Ca2+ channel) and calsequestrin, a luminal Ca2+-binding protein. The complex formed by Jsrp1 and Cav1.1 is found to be decreased with age and has been linked to decayed muscle strength and physical disability in the elderly. Knock-out of this gene in young mice results in decreased expression of Cav1.1 and diminished muscle strength.
外形
Solution in phosphate buffered saline containing 0.05% sodium azide.
基本信息
| MDL编号 | MFCD02263551 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | diluted ascites fluid |
| antibody product type | primary antibodies |
| 克隆 | VF1C, monoclonal |
| 分子量 | antigen 90 kDa |
| species reactivity | canine, mouse, rat, guinea pig, rabbit |
| technique(s) | indirect immunofluorescence: suitable western blot: suitable |
| UniProt登记号 | Q3MI48 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Jsrp1(71912) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
