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Interleukin-12 from mouse

品牌
Sigma-Aldrich
货号
I8523
规格纯度
≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
参考价格
3684.93 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Interleukin-12 (IL-12) from mouse has been used to study the effect of IL-12 on Th1 (type 1 T helper) immunity in Mongolian gerbils (Meriones unguiculatus) infected with Sporothrix schenckii. It has been used as a standard in ELISA (enzyme-linked immunosorbent assay) cytokine assay.

生化/生理作用

Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

基本信息

MDL编号MFCD00212975

产品性质

质量水平100
生物来源mouse
重组expressed in baculovirus infected Sf21 cells
测定≥97% (SDS-PAGE)
形式lyophilized powder
效能0.02-0.4 ng/mL EC50
分子量glycoprotein 70 kDa
包装pkg of 10 μg
technique(s)cell culture | mammalian: suitable
杂质 endotoxin, tested
UniProt登记号P43431, P43432
储存温度−20℃
Gene Informationmouse ... Il12a(16159), Il12b(16160)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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