Anti-Inositol 1,4,5-Triphosphate Receptor (Type II) antibody produced in rabbit

产品说明

一般描述

The gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) encodes type 2 intracellular receptor that binds to Inositol 1,4,5 trisphosphate. The gene encodes a 2701 amino acid protein that contains six membrane-spanning regions near the C-termini. The cytoplasmic N-terminal domain is involved in ligand-binding. The gene is mapped to human chromosome 12p11.

免疫原

synthetic petide with a sequence derived from the cytoplasmic, amino-terminus of rat IP3R-II.

生化/生理作用

The receptor encoded by the gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) is a Ca²⁺ release channel in the endoplasmic reticulum that is stimulated upon binding to its ligand inositol 1,4,5-triphosphate. It mediates intracellular calcium signaling. It facilitates the release of Ca²⁺ from endoplasmic reticulum and modulates intracellular Ca²⁺ concentration. Loss of ITPR2 gene function is found to be associated with anhidrosis and can inhibit sweat production in humans and mice.

外形

Solution in PBS with 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质