Anti-Glutamate Receptor 4, Metabotropic antibody produced in rabbit

产品说明

免疫原

synthetic peptide corresponding to the N-terminal extracellular domain of human metabotropic glutamate receptor 4, conjugated to KLH. The immunizing peptide has 100% homology with the rat gene and 89% homology with the mouse gene.

应用

Anti-Glutamate Receptor 4, Metabotropic antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 3μg/mL using human neurons, cortex.

生化/生理作用

Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of group I appear to have a neuroprotective effect.

外形

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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