产品说明
应用
Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.
包装
10, 50 mg in glass bottle
生化/生理作用
Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.
特点和优势
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C16H16ClNO3 · CH4O3S |
| 分子量 | 401.86 |
| EC 号 | 266-612-7 |
| MDL编号 | MFCD04112986 |
| PubChem化学物质编号 | 329825223 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | white to tan |
| mp | 271 ℃ (lit.) |
| 溶解性 | DMSO: ≥15 mg/mL at ~60 ℃ |
| 储存温度 | room temp |
| SMILES string | CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23 |
| InChI | 1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4) |
| InChI key | CVKUMNRCIJMVAR-UHFFFAOYSA-N |
| Gene Information | human ... DRD1(1812) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 - H317 - H319 |
| 预防措施声明 | P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
