Anti-Fatty Acid Synthase antibody produced in rabbit

产品说明

一般描述

Fatty acid synthase (FAS, FASN) is encoded by the gene mapped to human chromosome 17q25.3.
Fatty acid synthase (FAS, FASN) is encoded by the gene mapped to human chromosome 17q25.3. In mammals, it is composed of two identical multifunctional polypeptides, in which three catalytic domains in the N-terminal section (β-ketoacyl synthase, malonyl/acetyl tansferase, and dehydrase) are separated by a core region of about 600 residues from four C-terminal domains (enoyl reductase, β-ketoacyl reductase, acyl carrier protein, and thioesterase).

免疫原

synthetic peptide corresponding to amino acids 1982-1999 of mouse fatty acid synthase, conjugated to KLH via an N-terminal added cysteine residue. The immunizing peptide is conserved in rat and differs from the human sequence by three amino acids.

应用

Anti-Fatty Acid Synthase antibody is suitable for western blot analysis at a concentration of 0.5-1μg/mL using lysates of mouse myoblast C2 cells and rat hepatocytoma FAO cells.
Fatty acid synthase antibody produced in rabbit has been used in immunohistochemistry and western blot analysis.

生化/生理作用

FAS plays an essential role during embryogenesis and energy homeostasis in adult animals. It also acts as the carbon source for fatty acid synthesis. It has been shown to be overexpressed in various types of human cancer, including prostate, breast, ovary and others. FASN is a multifunctional protein, mainly involved in catalyzing the synthesis of palmitate from acetyl-CoA and malonyl CoA, in the presence of NADPH.

目标描述

Fatty Acid Synthase encodes an enzyme that is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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