位置:首页 > 品牌 > Sigma-Aldrich >

Fractalkine, Chemokine Domain from mouse

品牌
Sigma-Aldrich
货号
F2302
规格纯度
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
参考价格
8375.19 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons.

生化/生理作用

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)-dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease. In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD.
Leukocyte chemoattractant protein and member of the chemokine superfamily possessing a CX3C motif. Mouse fractalkine is chemotactic for neutrophils and T-lymphocytes but not monocytes.

外形

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

分析说明

The biological activity is measured by its ability to chemoattract freshly isolated peripheral blood lymphocytes.

基本信息

MDL编号MFCD01635336
NACRESNA.32

产品性质

质量水平100
生物来源mouse
重组expressed in E. coli
测定>97% (SDS-PAGE)
形式lyophilized powder
效能0.3-3 μg/mL
分子量calculated mol wt ~9.5 kDa
包装pkg of 25 μg
储存条件avoid repeated freeze/thaw cycles
杂质 endotoxin, tested
UniProt登记号O35188
储存温度−20℃
Gene Informationmouse ... Cx3cl1(20312)

安全信息

象形图GHS05
警示用语:Danger
危险声明H315 - H318
预防措施声明P280 - P305 + P351 + P338
危险分类Eye Dam. 1 - Skin Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号