EHNA, Hydrochloride-CAS 51350-19-7-Calbiochem

产品说明

一般描述

The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (K_i = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.

包装

10 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
PDE 2
Target K_i: 4 nM against adenosine deaminase
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 0.8 and 2 µM against human and procine PDE II, respectively

警告

Toxicity: Standard Handling (A)

其他说明

Burton, P., et al. 2010. Biochem. J.in press.
Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol.31, 401.
Verde, I., et al. 1999. Br. J. Pharmacol.127, 65.
Reynolds, A.J., et al. 1996. Brain Res.798, 67.
Mery, P.F., et al. 1995. Mol. Pharmacol.48, 121.
Podzuweit, T., et al. 1995. Cell. Signal.7, 733.
Bessodes, M., et al. 1982. Biochem. Pharmacol.31, 879.
Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA78, 1033.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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