产品说明
一般描述
Anti-endothelial cell protein C receptor antibody, rat monoclonal (EPCR) (rat IgG1 isotype) is derived from the RCR-252 hybridoma produced by the fusion of mouse SP2/0 myeloma cells and cells isolated from the superficial inguinal lymph nodes from Wister rats immunized with human EPCR-positive RE-1 cells. Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) is a protein encoded by the PROCR gene in humans. It is predominantly expressed in endothelial. The EPCR is also expressed in small vessels such as capillaries of the alveolar wall in the lung. EPCR is a member of the CD1/major histocompatibility complex superfamily.
免疫原
human EPCR-positive RE-1 cells.
应用
Anti-endothelial cell protein C receptor antibody, rat monoclonal has been used in flow cytometry (FACS analysis) and in blocking the binding of the antigen presenting cell (APC) ligand to the EPCR.
包装
200 μL in glass bottle
生化/生理作用
Endothelial protein C receptor (EPCR) is involved in regulation of the cytoprotective and anticoagulant pathways of protein C. EPCR plays an important role in regulating the inflammatory response. It is also identified as an endothelial receptor for specific P. falciparum erythrocyte membrane protein 1 (PfEMP1) subtypes. EPCR is associated with an increased risk of venous thromboembolism (VTE).
外形
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
MDL编号 | MFCD04118502 |
NACRES | NA.41 |
产品性质
质量水平 | 200 |
生物来源 | rat |
偶联物 | unconjugated |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | RCR-252, monoclonal |
形式 | buffered aqueous solution |
分子量 | antigen 49 kDa |
species reactivity | human |
technique(s) | flow cytometry: 5-20 μg/mL using HUVEC cells microarray: suitable |
同位素/亚型 | IgG1 |
UniProt登记号 | Q9UNN8 |
运输 | dry ice |
储存温度 | −20℃ |
Gene Information | human ... PROCR(10544) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |