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Phosphodiesterase 5A1 human

3′,5′-cyclic-GMP phosphodiesterase

品牌
Sigma-Aldrich
货号
E9034
规格纯度
recombinant, expressed in Sf9 cells
参考价格
7986.5 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Phosphodiesterase (PDE) is an enzyme that is used to breaks phosphodiester bonds. PDE5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. PDE5 is used to find novel PDE5 inhibitors .

生化/生理作用

PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis .

物理属性

N-terminal GST-tagged 126 kDa full-length protein

单位定义

One unit will convert 1.0 picomole of 3′,5′-cGMP to 5′-GMP per minute at pH 7.4 at 37 ℃.

外形

Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN® 20 and 3 mM DTT

法律信息

TWEEN is a registered trademark of Croda International PLC

基本信息

酶学委员会(EC)编号3.1.4.25 ( BRENDA | IUBMB )
NACRESNA.54

产品性质

质量水平200
重组expressed in Sf9 cells
形式solution
specific activity≥2,000 unit/μg protein
分子量 126 kDa
UniProt登记号O76074
运输dry ice
储存温度−70℃
Gene Informationhuman ... PDE5A(8654)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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