产品说明
免疫原
synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-5/S1P2 receptor.
应用
Anti-S1P2, C-Terminal antibody produced in rabbit is suitable for western blotting.
生化/生理作用
Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodeing a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.
外形
Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.
基本信息
| MDL编号 | MFCD02686109 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | fractionated antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~42 kDa by SDS-PAGE |
| species reactivity | human |
| 浓度 | ~1 mg/mL |
| technique(s) | western blot: suitable |
| UniProt登记号 | O95136 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... S1PR2(9294) |
