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Anti-EMMPRIN antibody produced in goat

品牌
Sigma-Aldrich
货号
E4029
规格纯度
affinity isolated antibody
参考价格
4294.63 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein encoded by the BSG gene in humans. It is also known as Basigin (BSG). It is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. Expression of CD147 is significantly higher in ectopic endometrial tissues in patients with endometriosis compared to normal endometrial tissues.

免疫原

purified recombinant human extracellular matrix metalloproteinase inducer extracellular domain, expressed in NSO cells.

应用

Anti-EMMPRIN antibody produced in goat is suitable for western blotting at a concentration of 0.1-0.2μg/mL.

生化/生理作用

CD147 functions as an extracellular matrix metalloproteinase inducer, regulates lymphocyte responsiveness, monocarboxylate transporter expression and spermatogenesis. It interacts with cyclophilin family and acts as a signaling receptor to extracellular cyclophilins A and B. EMMPRIN expression in epithelial ovarian cancers (EOC) is higher than in benign ovarian tumors and normal ovaries. It is associated with the pathogenesis of acute coronary syndrome (ACS) and may act as a biomarker for ACS. EMMPRIN plays important roles in tumor progression and sunitinib resistance in renal cell carcinoma (RCC). It could act as a novel target for the treatment of RCC.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD02262857
NACRESNA.41

产品性质

质量水平100
生物来源goat
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
species reactivityhuman
technique(s)western blot: 0.1-0.2 μg/mL
UniProt登记号P35613
储存温度−20℃
Gene Informationhuman ... BSG(682)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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