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Monoclonal Anti-S1P4, C-Terminal antibody produced in mouse

品牌
Sigma-Aldrich
货号
E9529
规格纯度
~1 mg/mL, clone 1, purified immunoglobulin, buffered aqueous solution
参考价格
14727.7 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

特异性

Specifically detects human recombinant and native EDG-6/S1P4 protein (approximately 45 kDa).

免疫原

synthetic peptide derived from the C-terminal region of the EDG-6/S1P4 protein.

应用

Anti-S1P4, C-Terminal antibody produced in rabbit is suitable for western blotting and flow cytometry at a working antibody concentration of 5-10μg/mL using RH7777 rat hepatoma cells transfected with EDG-6 protein.

生化/生理作用

Sphingosine-1-phosphate receptor 4 (S1PR4, EDG-6) is a human gene, which encodes a G protein-coupled receptor and is identified as an orphan G-protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P). EDG-6 is a member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is expressed in lymphoid, hematopoietic tissue and in the lung. EDG-6 acts as a high affinity receptor for SPP that couples to a G(i/o) protein leading to the activation of growth-related signaling pathways. It is one of the S1P or lysosphingolipid receptors that couples to phospholipase C-Ca2+ system through pertussis toxin-sensitive G-proteins.

分析说明

To detect native EDG-6/S1P4 in cells and tissues, use higher antibody concentrations.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD03454969
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆1, monoclonal
形式buffered aqueous solution
species reactivityhuman
浓度~1 mg/mL
technique(s)flow cytometry: suitable
western blot: suitable
同位素/亚型IgG1
UniProt登记号O95977
运输wet ice
储存温度−20℃
Gene Informationhuman ... S1PR4(8698)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

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