产品说明
一般描述
Three EDEM homologs, EDEM1, EDEM2 and EDEM3 have been identified, which are transcriptionally upregulated upon ER stress by the activated IRE1/Xbp-1 branch.
Monoclonal Anti-EDEM3 (mouse IgG1 isotype) is derived from the hybridoma EDEM3-1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human EDEM3 conjugated to KLH.
应用
Monoclonal Anti-EDEM3 antibody produced in mouse has been used in immunoblotting.
生化/生理作用
EDEM3 (ER degradation enhancer, mannosidase α-like 3), a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation (ERAD) and mannose trimming. EDEM3 accelerates ERAD of misfolded glycoproteins as well, but in ontrast to EDEM1, it greatly stimulates mannosidase trimming in vivo.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | EDEM3-1, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~120 kDa |
| species reactivity | rat, human, mouse |
| 浓度 | ~1.0 mg/mL |
| technique(s) | western blot: 1-2 μg/mL using whole extract of mouse 3T3 or rat NRK cells |
| UniProt登记号 | Q9BZQ6 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... EDEM3(80267) mouse ... Edem3(66967) rat ... Edem3(289085) |
