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Monoclonal Anti-E2F6 antibody produced in mouse

品牌
Sigma-Aldrich
货号
E1532
规格纯度
~1.0 mg/mL, clone TFE61, purified immunoglobulin, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

E2F6 transcription factor belongs to the third class of E2Fs. The E2F transcription factors are a family of genes that play critical roles in regulation of cellular proliferation and differentiation.

免疫原

recombinant human E2F6 protein

应用

Monoclonal Anti-E2F6 antibody produced in mouse is suitable for immunocytochemistry and indirect ELISA. It is also suitable for western blotting at a working concentration of 2-4μg/mL using HeLa nuclear cell extract.

生化/生理作用

The third class of E2Fs lacks both the retinoblastoma protein binding and transcriptional activation domain, and is an active repressor of transcription. The activity of E2F6 is mediated through its recruitment of polycomb transcriptional repressor complexes in a histone methylation independent manner. E2F6 associates with E2F target genes that are activated at G1/S phase. Its repression activity during the S-phase distinguishes G1/S and G2/M transcription during cell cycle. It may be involved in various cancerous processes.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆TFE61, monoclonal
形式buffered aqueous solution
分子量antigen ~35 kDa
species reactivityhuman
浓度~1.0 mg/mL
technique(s)immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 2-4 μg/mL using HeLa nuclear cell extract
同位素/亚型IgG1
UniProt登记号O75461
运输dry ice
储存温度−20℃
Gene Informationhuman ... E2F6(1876)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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