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Anti-Daxx antibody produced in rabbit

品牌
Sigma-Aldrich
货号
D7810
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
5775.59 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Death domain associated protein (Daxx), also known as ETS associated protein 1 (EAP1), is an adaptor protein that binds to the death domain of Fas. Daxx is a 120 kDa protein with a nuclear localization signal sequence. It is highly acidic due to extended glutamic acid-rich domains. Daxx mRNA is extensively expressed in fetal and adult human and mouse tissues. Daxx has also been found in the nucleus where it localizes with the promyelocytic leukemia protein (PML), a gene of acute promyelocytic leukemia (APL).

特异性

Anti-Daxx specifically recognizes human Daxx (120 kDa).

免疫原

Synthetic peptide corresponding to the C-terminus of human Daxx. This sequence is identical in mouse and monkey.

应用

Anti-Daxx antibody is suitable for:

  • western blot (1:4,000 using human acute lymphoma Jurkat whole cell extract)
  • microarray
  • the detection and localization of Daxx by immunoblotting


Anti-Daxx antibody produced in rabbit has been used to visualize hDaxx.

生化/生理作用

The death domain-associated protein (Daxx) is a protein that interacts with FAS and subsequently regulates cellular apoptosis. Daxx also interacts with H3.3 histone and α-thalassemia X-linked mental retardation protein (ATRX) to regulate chromatin deposition at telomeres. In addition, it also acts as a pro-apoptotic molecule that can specifically enhance Fas-induced apoptosis by activating the Jun N-terminal kinase (JNK) signaling pathway, through its interaction with the apoptosis signal-regulating kinase 1 (ASK1).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01865517
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 120 kDa
species reactivitymouse, monkey, human
technique(s)microarray: suitable
western blot: 1:4,000 using human acute lymphoma Jurkat whole cell extract
UniProt登记号Q9UER7
运输dry ice
储存温度−20℃
Gene Informationhuman ... DAXX(1616)
mouse ... Daxx(13163)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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