产品说明
一般描述
Death domain associated protein (Daxx), also known as ETS associated protein 1 (EAP1), is an adaptor protein that binds to the death domain of Fas. Daxx is a 120 kDa protein with a nuclear localization signal sequence. It is highly acidic due to extended glutamic acid-rich domains. Daxx mRNA is extensively expressed in fetal and adult human and mouse tissues. Daxx has also been found in the nucleus where it localizes with the promyelocytic leukemia protein (PML), a gene of acute promyelocytic leukemia (APL).
特异性
Anti-Daxx specifically recognizes human Daxx (120 kDa).
免疫原
Synthetic peptide corresponding to the C-terminus of human Daxx. This sequence is identical in mouse and monkey.
应用
Anti-Daxx antibody is suitable for:
- western blot (1:4,000 using human acute lymphoma Jurkat whole cell extract)
- microarray
- the detection and localization of Daxx by immunoblotting
Anti-Daxx antibody produced in rabbit has been used to visualize hDaxx.
生化/生理作用
The death domain-associated protein (Daxx) is a protein that interacts with FAS and subsequently regulates cellular apoptosis. Daxx also interacts with H3.3 histone and α-thalassemia X-linked mental retardation protein (ATRX) to regulate chromatin deposition at telomeres. In addition, it also acts as a pro-apoptotic molecule that can specifically enhance Fas-induced apoptosis by activating the Jun N-terminal kinase (JNK) signaling pathway, through its interaction with the apoptosis signal-regulating kinase 1 (ASK1).
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD01865517 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 120 kDa |
| species reactivity | mouse, monkey, human |
| technique(s) | microarray: suitable western blot: 1:4,000 using human acute lymphoma Jurkat whole cell extract |
| UniProt登记号 | Q9UER7 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... DAXX(1616) mouse ... Daxx(13163) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
