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Anti-CD4 (mouse), redFluor® 710, clone GK1.5

品牌
Sigma-Aldrich
货号
MABF157C
规格纯度
clone GK1.5, from rat, redFluor® 710
参考价格
4009.62 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will “compete” for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.

免疫原

Immunogen information for this antibody is proprietary information.

应用

Research Sub Category
Immunoglobulins & Immunology
This rat monoclonal Anti-CD4 Antibody (Mouse), redFluor® 710, clone GK1.5, Cat. No. MABF1575 is validated for use in Flow Cytometry, for the detection of CD4.
Research Category
Inflammation & Immunology

质量

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 μg from a representative lot detected CD4 in one million C57Bl/6 splenocytes.

外形

Purified Rat monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Purified by size-exclusion chromatography

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.
Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

其他说明

Concentration: Please refer to lot specific datasheet.

法律信息

redFluor is a registered trademark of Tonbo Biotechnologies

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源rat
偶联物redFluor® 710
抗体形式purified antibody
antibody product typeprimary antibodies
克隆GK1.5, monoclonal
species reactivitymouse
包装antibody small pack of 25 μg
technique(s)flow cytometry: suitable
同位素/亚型IgG2bκ
UniProt登记号P06332

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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