产品说明
一般描述
As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells. It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base. However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts. These membrane microdomains are thought to function as signaling platforms that regulate the localization and interactions of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts — it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.
Sphingomyelin and related lipids
应用
Milk SM is suitable:
- for detecting ceramide in feces
- for differential scanning calorimetry
- as a lipid standard
包装
5 mL Clear Glass Sealed Ampule (860063C-25mg)
产品性质
| 测定 | >99% (TLC) |
| 包装 | pkg of 1 × 2.5 mL (860063C-25mg) |
| manufacturer/tradename | Avanti Polar Lipids 860063C |
| 浓度 | 10 mg/mL (860063C-25mg) |
| 运输 | dry ice |
| 储存温度 | −20℃ |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 |
| 预防措施声明 | P201 - P260 - P264 - P280 - P304 + P340 + P311 - P403 + P233 |
| 危险分类 | Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3 |
| 靶器官 | Central nervous system |
| 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | does not flash |
| 闪点(C) | does not flash |
