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Carbonic Anhydrase II human

碳酸酐酶 II 人

品牌
Sigma-Aldrich
货号
C6624
规格纯度
recombinant, expressed in E. coli, buffered aqueous solution
参考价格
6403.71 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Human carbonic anhydrase II has been used in a study to assess quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion. Human carbonic anhydrase II has also been used in a study to investigate a new scrubber concept for catalytic CO2 hydration.

生化/生理作用

Carbonic anhydrase is a zinc metalloenzyme that catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in vital physiological and pathological processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. It is required for renal acidification. Its absence can lead to osteoporosis, renal tubular acidosis, and cerebral calcification. Therefore, this enzyme is an important target for inhibitors with clinical applications in glaucoma, epilepsy and Parkinson′s disease. In addition, it is being explored as a potential target for obesity and cancer. CAII has a molecular mass of approximately 30 kDa and is primarily present in type II pneumocytes. Due to this unique location it has been speculated that CAII is involved in pulmonary functions such as regulation of fluid secretion and facilitation of CO2 elimation. Sulfonamides, sulfamates and sulfamides are potent inhibitors of CA.

单位定义

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0 ℃. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

外形

Supplied as a solution in 20 mM Tris, pH 7.5, with 150 mM NaCl.

基本信息

酶学委员会(EC)编号4.2.1.1 ( BRENDA | IUBMB )
MDL编号MFCD01634577
NACRESNA.54

产品性质

质量水平200
重组expressed in E. coli
形式buffered aqueous solution
specific activity≥5,000 units/mg protein
分子量large subunit 17-22 kDa
small subunit 10-12 kDa
浓度800-1000 μg/mL
NCBI登记号NM_000067
NP_000058
运输wet ice
储存温度−20℃
Gene Informationhuman ... CA2(760)

安全信息

储存分类代码12 - Non Combustible Liquids

Sigma-Aldrich

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