产品说明
应用
Torsemide has been used as an inhibitor of Na+ Cl- co-transporter in transgenic Arabidopsis thaliana plants1.
包装
10, 50 mg in glass bottle
生化/生理作用
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.
Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure2.
特点和优势
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
制备说明
Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.
其他说明
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T3202.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
基本信息
| 经验(实验)分子式 | C16H20N4O3S |
| 分子量 | 348.42 |
| MDL编号 | MFCD00866166 |
| PubChem化学物质编号 | 329826741 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 溶解性 | DMSO: soluble 18 mg/mL H2O: insoluble |
| 创始人 | Roche |
| SMILES string | CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2 |
| InChI | 1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) |
| InChI key | NGBFQHCMQULJNZ-UHFFFAOYSA-N |
| Gene Information | human ... SLC12A1(6557) |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H319 - H361fd |
| 预防措施声明 | P201 - P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313 |
| 危险分类 | Eye Irrit. 2 - Repr. 2 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
