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Carmofur

卡莫氟

品牌
Sigma-Aldrich
CAS
61422-45-5
货号
C1494
规格纯度
≥98% (HPLC), powder
参考价格
1122.16 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

包装

10, 50 mg in glass bottle

生化/生理作用

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.
Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (Mpro) in vitro.

基本信息

经验(实验)分子式C11H16FN3O3
分子量257.26
MDL编号MFCD00866284
PubChem化学物质编号329774890
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to off-white
溶解性DMSO: >15 mg/mL
储存温度2-8℃
SMILES stringCCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
InChI1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
InChI keyAOCCBINRVIKJHY-UHFFFAOYSA-N

安全信息

象形图GHS06GHS08
警示用语:Danger
危险声明H301 - H361
预防措施声明P201 - P301 + P310 + P330
危险分类Acute Tox. 3 Oral - Repr. 2
储存分类代码6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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