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Ebastine

品牌
Sigma-Aldrich
CAS
90729-43-4
货号
E9531
规格纯度
≥98% (HPLC), solid
参考价格
3088.72 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Ebastine is metabolised by cytochrome P450 3A (CYP3A4) to carebastine. It is used to treat allergic rhinitis and chronic idiopathic urticaria.

应用

Ebastine has been used as a cationic amphiphilic drug (CAD) in sensitizing cancerous cells to chemotherapy and revert multidrug resistance.

包装

10, 50 mg in glass bottle

生化/生理作用

Ebastine is a non-sedating histamine H1 receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.

特点和优势

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C32H39NO2
分子量469.66
MDL编号MFCD00865661
PubChem化学物质编号329799086
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 white
溶解性DMSO: >10 mg/mL
H2O: insoluble
储存温度room temp
SMILES stringCC(C)(C)c1ccc(cc1)C(=O)CCCN2CCC(CC2)OC(c3ccccc3)c4ccccc4
InChI1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3
InChI keyMJJALKDDGIKVBE-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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