产品说明
应用
Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves. It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.
包装
10, 50 mg in glass bottle
生化/生理作用
Ibandronate sodium inhibits farnesyl diphosphate synthase (IC50 = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.
Ibandronate is a nitrogen-containing bisphosphonate (N-BP). It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.
特点和优势
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
基本信息
| 经验(实验)分子式 | C9H22NNaO7P2 |
| 分子量 | 341.21 |
| MDL编号 | MFCD07197214 |
| PubChem化学物质编号 | 329815388 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥97% (NMR) |
| 形式 | solid |
| 储存条件 | protect from light |
| 颜色 | white |
| 溶解性 | H2O: >10 mg/mL |
| 创始人 | Roche |
| 储存温度 | 2-8℃ |
| SMILES string | [Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O |
| InChI | 1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1 |
| InChI key | LXLBEOAZMZAZND-UHFFFAOYSA-M |
| Gene Information | human ... FDPS(2224) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
