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Biliverdin Reductase A human

品牌
Sigma-Aldrich
货号
B3687
规格纯度
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous solution
参考价格
6327.21 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Biliverdin reductase catalyzes the transformation of the blue-green pigment biliverdin IX to the yellow-orange bile pigment bilirubin IX by converting a double-bond between the second and third pyrrole ring into a single-bond. This enzyme has two distinct cofactor-dependent pH optima. In the acidic range of pH 6.0-6.7, NADH is utilized, whereas in the alkaline range of pH 8.5-8.7, NADPH is utilized. Biliverdin reductase is considered a major physiologic cytoprotectant. Biliverdin reductase suppresses experimental autoimmune encephalomyelitis in rats. Depletion of biliverdin reductase leads to accumulation of cellular oxidants and augmented cell death.

单位定义

1 unit of biliverdin reductase will trans­form 1 nanomole of biliverdin to bilirubin per minute in an NADPH dependent reaction at pH 8.5 using 100 mM K-phosphate buffer at 37 ℃.

外形

Solution containing 20 mM potassium phosphate buffer, 10% glycerol, 0.2% Igepal CA630, 1 mM EDTA, and 0.1 mM DTT.

基本信息

NACRESNA.32

产品性质

质量水平200
重组expressed in E. coli
测定≥90% (SDS-PAGE)
形式buffered aqueous solution
specific activity≥700 units/mg protein
运输dry ice
储存温度−20℃
Gene Informationhuman ... BLVRA(644)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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