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CI-1033

卡纽替尼二盐酸盐

品牌
Sigma-Aldrich
CAS
289499-45-2
货号
C7249
规格纯度
≥98% (HPLC)
参考价格
818.83 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range for EGFR, HER2, and ErbB-4.

特点和优势

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式C24H25ClFN5O3· 2HCl
分子量558.86
MDL编号MFCD09954112
PubChem化学物质编号329775143
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
溶解性DMSO: >10 mg/mL
H2O: >10 mg/mL
储存温度−20℃
SMILES stringCl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
InChI1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
InChI keyJZZFDCXSFTVOJY-UHFFFAOYSA-N
Gene Informationhuman ... EGFR(1956), ERBB2(2064), ERBB4(2066)

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P261 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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