产品说明
生化/生理作用
EphA1 (ephrin receptor A1) plays an essential role in development, and is involved in the guidance of axonal and cell migration in nervous system. Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same. It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target. Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri. In esophageal squamous cells, it acts as differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.
Member of ephrin ligand family that binds Eph receptor tyrosine kinases (EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7 and EphB1). Involved in pattern formation and morphogenesis. Ephrin-A1 can be detected on fetal osteoblasts, odotoblasts, chondrocytes, and squamous epithelium. Ephrin-A1 is expressed during embryonic vasculogenesis and during tumor-induced angiogenesis.
其他说明
Extracellular domain of mouse ephrin-A1 (amino acids 1-182) fused to the C-terminal 6X histidine-tagged Fc region of human IgG.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
分析说明
The biological activity is measured by its ability to bind recombinant mouse EphA2/Fc in ELISA.
基本信息
| MDL编号 | MFCD01867530 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 重组 | expressed in NSO cells |
| 测定 | >90% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | 0.16-10 ng/mL |
| 分子量 | monomer calculated mol wt 46.8 kDa 50-55 kDa by SDS-PAGE (reducing) |
| 包装 | pkg of 200 μg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| 杂质 | endotoxin, tested |
| UniProt登记号 | P20827 |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Efna1(13636) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
