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Human Chondrocytes-Osteoarthritis: HC-OA, adult

品牌
Sigma-Aldrich
货号
402OA-05A
包装型号
规格纯度
参考价格
13028.9 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

HC-OA Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis (OA). Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage. Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development. Thus, HC-OA provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the OA joint.

Characterization: Positive for aggrecan after differentiation.

HC-OA have been used to demonstrate that THF-alpha activates transcription of ADAMTS-4, a metalloproteinase implicated in cartilage degradation in OA, via p38-MAPK-dependent mechanism (Xue, 2013).

细胞系来源

Cartilage

应用

model for studying chondrocyte biology in an osteoarthritis joint

组分

Basal Medium containing 10% FBS & 10% DMSO

制备说明

  • 1st passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
  • Can be cultured at least 10 doublings

传代培养常规

Please refer to the HC-OA Culture Protocol.

基本信息

NACRESNA.81

产品性质

生物来源human articular cartilage (osteoarthritic)
质量水平100
包装pkg of 500,000 cells
生长模式Adherent
核型2n = 46
形态学chondrocyte
technique(s)cell culture | mammalian: suitable
相关疾病arthritis
运输dry ice
储存温度−196℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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