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Anti-hABH3 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
A8353
规格纯度
clone hABH3-99, purified from hybridoma cell culture
参考价格
4692 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Human alkB homolog 3, alpha-ketoglutarate dependent dioxygenase (hABH3) is mainly found in the nucleoplasm and cytoplasm. Anti-hABH3 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hABH3-99 hybridoma produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with hABH3, conjugated to keyhole limpet hemocyanin (KLH).

特异性

Mouse Monoclonal Anti-hABH3 binds to human, monkey, bovine, dog, rat, hamster, and mouse hABH3. It does not recognize hABH1 or hABH2. The antibody epitope resides within amino acids 2-16 of human hABH3.

应用

Mouse Monoclonal Anti-hABH3 can be used for western blot (1-2μg/mL), immunohistochemistry, immunoprecipitation, indirect ELISA and microarray studies.

  • Mouse Monoclonal Anti-hABH3 has been used in:
  • western blot
  • immunohistochemistry
  • immunoprecipitation
  • indirect enzyme linked immunosorbent assay (ELISA)

生化/生理作用

Human alkB homolog 3, α-ketoglutarate dependent dioxygenase (hABH3) is involved in the repair of alkylated RNA. This antibody serves as an important tool for studying the regulation of DNA/RNA repair enzymes.
hABH3 is a Fe(II)-dependent dioxygenase involved in the repair of alkylation-induced damage in DNA. hABH3 mutations have been analysed in pediatric brain tumors.
Mouse Monoclonal Anti-hABH3 binds to human, monkey, bovine, dog, rat, hamster, and mouse hABH3. It does not recognize hABH1 or hABH2. The antibody epitope resides within amino acids 2-16 of human hABH3.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD06412252
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆hABH3-99, monoclonal
形式buffered aqueous solution
分子量antigen ~33 kDa
species reactivitymonkey, bovine, mouse, hamster, human, canine, rat
technique(s)immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1-2 μg/mL using total cell extract of 293T cells
同位素/亚型IgG1
UniProt登记号Q96Q83
运输dry ice
储存温度−20℃
Gene InformationMonkey ... ALKBH3(715921)
human ... ALKBH3(221120)
mouse ... Alkbh3(69113)
rat ... Alkbh3(362169)

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