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Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt

品牌
Sigma-Aldrich
货号
A3227
规格纯度
≥98% (HPLC), lyophilized powder
参考价格
2427.59 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

Amino Acid Sequence

Ala-Tyr-Pro-Gly-Lys-Phe-NH2

一般描述

Ala-Tyr-Pro-Gly-Lys-Phe-NH2 (AYPGKF- NH2) is a selective, specific proteinase-activated receptor 4 (PAR4) agonist peptide. PAR4 is a G-protein-coupled receptor that is expressed on the surface of human platelets and is involved in the thrombin signaling pathway. Cleavage of PAR4 by the protease thrombin stimulates the receptor and results in signaling of platelet aggregation.

应用

4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.
AYPGKF- NH2 may be used for probing PAR4 signaling in culture systems and in platelets.

包装

1 mg in glass bottle

生化/生理作用

AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation. Additionally, AYPGKF mediates the thrombin-induced release of endostatin from rat platelets.

基本信息

经验(实验)分子式C34H48N8O7 · xC2HF3O2
分子量680.79 (free base basis)
MDL编号MFCD04974484
PubChem化学物质编号329770819
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式lyophilized powder
颜色 white
溶解性H2O: >10 mg/mL
储存温度−20℃
SMILES stringOC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCCC2C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
InChI1S/C34H48N8O7.C2HF3O2/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22;3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46);(H,6,7)/t21-,25-,26-,27-,28-;/m0./s1
InChI keyBGPJLFVICWHITH-HKJXYENISA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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