Anti-ASK-1, C-terminal antibody produced in rabbit

产品说明

一般描述

ASK1 (Apoptosis Signal-regulating Kinase 1) also known as MAPKKK5 (Mitogen activated protein kinase kinase kinase 5) activates JNK and p38 signaling cascades. ASK-1 is activated in response to stress such as UV and X-ray radiation, proinflammatory cytokines such as TNF-α, heat shock or osmotic shock. Overexpression of ASK1 induces apoptotic cell death. Other signalling molecules such as PP5 and reactive oxygen species regulate the pro-apoptotic signalling by ASK1 hence act as negative regulators. ASK1 has pivotal function also in a broad range of biological activities and aids the cells in adapting to varied stress factors and in induction of immune responses.
Anti-ASK1 specifically recognizes human ASK1 (155 kDa).

免疫原

synthetic peptide corresponding to amino acids 1356-1375 of the human C-terminal region of ASK1.

应用

A concentration of 1 μg/mL of anti-ASK-1 is recommended for detection by immunoblotting in whole cell extract of SW1353 human chondrosarcoma cells.

数量

Reagent is sufficient for 10 blots.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质