产品说明
一般描述
TBTU and HBTU are two of the most popular in situ activation reagents used in solid phase and solution phase peptide synthesis [1-9]. These reagents offer reactivity similar to symmetrical anhydrides and BOP [1]. Couplings proceed smoothly and rates can even be enhanced by the addition of HOBt [2, 4, 5, 6]. In addition to having high reactivity, TBTU and HBTU have also been shown to limit enantiomerization during fragment condensation and during DMAP catalyzed esterification of arginine derivatives [3]. Comparative experiments between HBTU and TBTU have shown that the counter ion has no influence on coupling rates or levels of enantiomerization [1].
The product number for this product was previously 01-62-0010.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
联系
Replaces: 01-62-0010
分析说明
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
法律信息
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C11H16F6N5OP |
| 分子量 | 379.24 |
| MDL编号 | MFCD00075445 |
| EC索引号 | 423-020-5 |
产品性质
| 质量水平 | 300 |
| 产品线 | Novabiochem® |
| 测定 | ≥99.0% (HPLC) |
| 形式 | powder |
| 效能 | >2000 mg/kg LD50, oral (Rat) |
| reaction suitability | reaction type: Coupling Reactions |
| manufacturer/tradename | Novabiochem® |
| pH值(酸碱度) | 4.1 (1.6 g/L in H2O) |
| mp | 250 ℃ |
| 溶解性 | 1.6 g/L |
| application(s) | peptide synthesis |
| 储存温度 | 2-8℃ |
| InChI | 1S/C11H16N5O/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16/h5-8H,1-4H3/q+1 |
| InChI key | CLZISMQKJZCZDN-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H315 - H317 - H319 - H334 - H335 |
| 预防措施声明 | P261 - P264 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
