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T-bet (MRQ-46) Rabbit Monoclonal Antibody

品牌
Sigma-Aldrich
货号
368R-7
包装型号
规格纯度
参考价格
2428.74 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th)1 T-cell development from naïve T-helper precursor cells (Thp) and redirects Th2 T-cells to Th1 development. Anti-T-bet is a marker of mature T-cells and is expressed at very low levels in Thp cells and is absent in precursor T-lymphoblastic leukemia/lymphoma cells. Scattered small lymphocytes in the interfollicular T-cell zone of reactive lymphoid tissue, including tonsil, lymph node, and spleen exhibited nuclear staining for anti-T-bet, with no anti-T-bet staining observed in germinal centers or mantle or marginal zones. T-bet is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma), and B-cell neoplasms derived from mature B-cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia. In contrast, B-cell neoplasms derived from pre-germinal center or germinal center B-cells, including mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma are negative for anti-T-bet. Therefore, anti-T-bet should serve as a useful marker for the diagnosis and subtyping of B-cell and T-cell lymphoproliferative disorders.

质量


IVD

IVD

IVD

RUO

联系

T-bet Positive Control Slides, Product No. 368S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平500
100
偶联物unconjugated
抗体形式culture supernatant
antibody product typeprimary antibodies
克隆MRQ-46, monoclonal
描述For In Vitro Diagnostic Use in Select Regions (See Chart)
形式buffered aqueous solution
species reactivityhuman
包装vial of 0.1 mL concentrate (368R-74)
vial of 0.5 mL concentrate (368R-75)
bottle of 1.0 mL predilute (368R-77)
vial of 1.0 mL concentrate (368R-76)
bottle of 7.0 mL predilute (368R-78)
manufacturer/tradenameCell Marque
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
同位素/亚型IgG1
控制tonsil
运输wet ice
储存温度2-8℃
可视化nuclear

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