位置:首页 > 品牌 > Sigma-Aldrich >

Anti-LAP2 Antibody

品牌
Sigma-Aldrich
货号
06-1002
规格纯度
from rabbit, purified by affinity chromatography
参考价格
5520.38 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The inner membrane of the nuclear envelope is connected to the nuclear lamina. The main components of the nuclear lamina are Type V intermediate filaments called lamins and lamin binding proteins including lamin B receptor, emerin, MANI, LAP1 (3 isoforms), and LAP2 (several isoforms). The lamins are divided into two groups: the constitutively expressed lamin B and the developmentaly regulated lamin A.
The best characterized isoforms of lamin binding protein LAP2 are LAP2α and LAP2β. LAP2β is a type II membrane protein in the inner nuclear membrane that binds lamin B and is important to cell viability and controlling nuclear lamina growth. LAP2α has been characterized as a nucleoplasmic protein that interacts with A-type lamins to control gene expression, transcription, and chromatin organization.

特异性

Predicted to cross-react with canine (dog) and rat based on sequence homology.
This antibody recognizes LAP2.

免疫原

KLH-conjugated synthetic linear peptide corresponding to LAP2.

应用

Research Sub Category
Cytoskeletal Signaling
Anti-LAP2 Antibody is an antibody against LAP2 for use in WB, IC & IF.
Immunofluorescence:
Representative lot data. This antibody was used to detect the nuclear lamina by immunofluorescence.

Immunocytochemistry:
Representative lot data.
A previous lot was used in confocal fluorescent analysis of A431, HeLa and NIH/3T3 cells using anti-LAP2 rabbit polyclonal antibody (Red).
Actin filaments have been labeled with AlexaFluor 488 -Phalloidin (Green). Nuclear is stained with DAPI (Blue). Positive nuclear staining.

Research Category
Epigenetics & Nuclear Function

质量

Evaluated by western blot on HeLa cell lysate.

Western Blot Analysis:
A 1:1000-1:3000 dilution of this antibody was used to detect LAP2 in HeLa cell lysate.

目标描述

~55 kDa

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, (pH 7.4), 150 mM NaCl, with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8ºC from date of receipt.

分析说明

Control
HeLa cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman, mouse, rat, canine
technique(s)immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable
NCBI登记号NM_003276
UniProt登记号P42167
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号