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Anti-SynGAP Antibody

品牌
Sigma-Aldrich
货号
06-900
规格纯度
Upstate®, from rabbit
参考价格
5520.38 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.

特异性

SynGAP

免疫原

peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1274-1293 of rat SynGAP-a

应用

Research Sub Category
Synapse & Synaptic Biology
Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.
Research Category
Neuroscience
Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).

联系

Replaces: 04-1071

外形

Format: Purified
Protein A purified
Purified in PBS with 0.05% NaN3 and 30% Glycerol

储存及稳定性

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式purified antibody
antibody product typeprimary antibodies
克隆polyclonal
species reactivityrat
manufacturer/tradenameUpstate®
technique(s)immunocytochemistry: suitable
western blot: suitable
NCBI登记号NM_006772.1
UniProt登记号Q96PV0
运输dry ice
Gene Informationhuman ... SYNGAP1(8831)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2

Sigma-Aldrich

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