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Anti-Rab11-FIP1/RCP Antibody

品牌
Sigma-Aldrich
货号
ABC513
规格纯度
from rabbit, purified by affinity chromatography
参考价格
6022.61 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The protein Rab11-FIP1/RCP, or alternatively named Rab11 family-interacting protein 1, or Rab-coupling protein, and encoded by the human gene RAB11FIP1/RCP is an effector protein that interacts with Rab11 in the processes surrounding endosomal recycling. Rab11-FIP1/RCP also is involved in membrane trafficking in phagocytosis, as well as during axon growth, mediating integrin trafficking in various cancers. RAB11-FIP1/RCP has isoforms. Isoform 1 is non-membrane bound and is localized in the endosome and is involved in endosome recycling. Isoform 2 is more cytoplasmic being confined, for example, to the cytoplasmic phagosome vesicles and the phagosome membrane. Rab11-FIP1/RCP is expressed in multiple tissues and comprises one member of a large family of Rab11 family interacting proteins (Fab11-FIPs) that define discrete subdomains and carry out temporally distinct roles within the recycling and membrane trafficking system of the cell.

免疫原

GST-tagged recombinant protein corresponding to human Rab11-FIP1/RCP.

应用

Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
This Anti-Rab11-FIP1/RCP Antibody is validated for use in western blotting, ICC & IP for the detection of Rab11-FIP1/RCP.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Rab11-FIP1/RCP in 10 µg of C2C12, HEK293, HeLa, HepG2, HUVEC, Jurkat, L6, NIH/3T3, PC-12, PC-3, RAW264.7 cell lysate.

Western Blotting Analysis: A representative lot from an independent laboratory detected Rab11-FIP1/RCP in Tac-TGN38 expressing HeLa cell lysates (Jing, J., et al. (2010). Mol Cell Biol. 21(17):3041-3053.).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Rab11-FIP1/RCP in Tac-TGN38 expressing HeLa cells (Jing, J., et al. (2010). Mol Cell Biol. 21(17):3041-3053.).

Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Rab11-FIP1/RCP from HeLa cell lysate (Jing, J., et al. (2010). Mol Cell Biol. 21(17):3041-3053.).

质量

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Rab11-FIP1/RCP in 10 µg of A431 cell lysate.

目标描述

~90 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

外形

Affinity purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityrat, mouse, human
technique(s)immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI登记号NP_001002814
UniProt登记号Q6WKZ4
运输wet ice
Gene Informationhuman ... RAB11FIP1(80223)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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