产品说明
一般描述
Sirtuin 6 (Sirt6) is a nuclear, chromatin-associated protein. Sirt6 is a member of Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.
免疫原
synthetic peptide corresponding to amino acids 330-348 of human Sirt6.
应用
Anti-Sirt6 (C-terminal) antibody has been used in
- immunoblotting
- immunofluorescence
- western blotting
- immunohistochemistry
生化/生理作用
Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD+ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~40 kDa |
| species reactivity | human |
| 浓度 | ~1 mg/mL |
| technique(s) | indirect immunofluorescence: suitable western blot: 0.5-1 μg/mL using whole extracts of human U87 cells western blot: 2.5-5 μg/mL using human HeLa cells |
| UniProt登记号 | Q8N6T7 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SIRT6(51548) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
