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Anti-RYR2 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4502707
规格纯度
affinity isolated antibody
参考价格
6363.8 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

RYR2 (ryanodine receptor 2) is an intracellular Ca2+ release channel present on the sarcoplasmic reticulum (SR). It forms tetramer with four types 2 RyR polypeptides (RyR2) and four FK506 binding proteins (FKBP12.6).
Anti-RYR2 Antibody detects endogenous levels of total RYR2 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human RyR2.

Immunogen Range: 2774-2823

应用

Anti-RYR2 antibody produced in rabbit is suitable for immunohistochemistry and indirect ELISA.

生化/生理作用

RYR2 (ryanodine receptor 2) provides guidance to the release and transport of Ca2+ from sarcoplasmic reticulum (SR) to the cytoplasm during cardiac muscle excitation-contraction (EC) coupling. Protein kinase A (PKA) phosphorylated RYR2 separates (FKBP12.6) to regulate the channel open probability (Po). During the process, a small portion of Ca2+ enter into the cell through the L-type Ca2+ channel, which further activates the RyR2 channel upon membrane depolarization. The activated RyR2 channel releases a large amount of Ca2+ from the SR and subsequent muscle contraction. Missense mutations in this gene cause Kazakh idiopathic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 564 kDa
species reactivitymouse, rat, human
浓度~1 mg/mL
technique(s)ELISA: 1:1000
immunohistochemistry: 1:50-1:100
NCBI登记号Q92736
UniProt登记号Q92736
运输wet ice
储存温度−20℃
Gene Informationhuman ... RYR2(6262)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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